Daily Exam Question - Feb. 10, 2014 - OB

By drwall
February 10, 2014

The most common manifestation of congenital rubella is:

A. Intracranial calcification
B. Intrauterine growth restriction
C. Sensorineural hearing loss
D. Microcephaly
E. Patent Ductus
Answer: B 

Pg. 1127, Gabbe 6th Ed. The most common manifestation of congenital rubella infection is growth restriction. Sensorineural hearing loss is the most common single defect associated with CRS, affecting up to  90% of congenitally infected infants, and the rate of hearing loss ins inversely related to the GA of the congenital rubella infection.  When infection occurs prior to 12 weeks gestation, other common defects include cardiac lesions 13%, most commonly patent Ductus arteriosus, and eye defects 13% such as cataracts glaucoma or retinitis. Other findings consistent with CRS include microopthalmia microcephaly, Cerebral Palsy,  mental retardation and IUGR  Most of these findings are seen only in fetuses infected within the first 12 weeks of GA, however, virtually all fetuses infected prior to the 11th week of GA have CRS.


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